What question did this study set out to answer?

This study aims to evaluate the correlation between MRD dynamics during oral azacitidine maintenance therapy and clinical outcomes in favorable-risk AML.

May 10, 2026Annals of HematologyOpen Access

MRD conversion during oral azacitidine maintenance correlates with outcomes in predominantly favorable-risk AML

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Authors

NHNoa HurvitzHebrew University of Jerusalem IAIrina AmitaiTel Aviv University ILIlana LevyTechnion – Israel Institute of Technology

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Implication

Retrospective study finds oral azacitidine maintenance improves outcomes in favorable-risk AML, suggesting MRD monitoring implications.

Key Points

This study aims to evaluate the correlation between MRD dynamics during oral azacitidine maintenance therapy and clinical outcomes in favorable-risk AML.
Conducted a multicenter, real-world retrospective study involving 30 favorable-risk AML patients treated with oral azacitidine maintenance.
Assessed MRD longitudinally using standardized molecular and flow-based assays.
Analyzed outcomes based on MRD status at the start of maintenance and during therapy.
At the start of oral azacitidine, 47% of patients were MRD-positive; 64% converted to MRD negativity during maintenance.
Relapse-free survival was comparable between MRD-negative patients and those who converted (24-month RFS 577 vs. 638 days).
Patients with persistent MRD positivity had significantly early relapse (24-month RFS 63 days), but overall survival did not differ significantly between MRD-defined groups.

Cite This Study

Hurvitz et al. (2026) studied this question.

synapsesocial.com/papers/6a00210dc8f74e3340f9bd63 https://doi.org/10.1007/s00277-026-07054-5

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MRD conversion during oral azacitidine maintenance correlates with outcomes in predominantly favorable-risk AML

Discussion

Member takes

Implication

Key Points

Cite This Study

MRD conversion during oral azacitidine maintenance correlates with outcomes in predominantly favorable-risk AML

Discussion

Member takes

Implication

Key Points

Cite This Study

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