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The study investigates the relationship between carbohydrate active enzymes and virulence in Clostridium perfringens.

Pangenome analysis of Clostridium perfringens and its virulence association with Carbohydrate Active Enzymes

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Analysis uncovers virulence associations of carbohydrate active enzymes in Clostridium perfringens, suggesting implications for pathogen management.

The study investigates the relationship between carbohydrate active enzymes and virulence in Clostridium perfringens.
Analyzed 126 publicly available C. perfringens genomes
Clustered genomes into three clades using pangenome analysis
Identified associations between CAZymes, virulence genes, and antimicrobial resistance
Clade 1 associated with avian necrotic enteritis enriched for glycosyl hydrolase GH18
Antimicrobial resistance genes found exclusively in clade 1
Average number of CAZymes per clade: 101.50 for clade 1, 104.31 for clade 2, 96.45 for clade 3

Bhattarai et al. (2026) studied this question.

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Analysis uncovers virulence associations of carbohydrate active enzymes in Clostridium perfringens, suggesting implications for pathogen management.