What question did this study set out to answer?

To compare the clinical outcomes of percutaneous coronary intervention (PCI) guided by various imaging and physiological methods against traditional angiography.

March 31, 2026Journal of the American Heart AssociationOpen Access

Comparison of Intravascular Imaging–, Physiology‐, or Angiography‐Guided Approaches for Percutaneous Coronary Intervention: A Systematic Review and Network Meta‐Analysis

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Authors

TSTetsuya SaitoEdogawa Hospital TATadao AikawaJichi Medical University YKYuko KiyoharaCleveland Clinic

Discussion

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Implication

A systematic review compares clinical outcomes of different guidance techniques for PCI, suggesting improved approaches.

Key Points

To compare the clinical outcomes of percutaneous coronary intervention (PCI) guided by various imaging and physiological methods against traditional angiography.
Conducted a systematic review and network meta-analysis of randomized controlled trials.
Reviewed studies comparing at least two of the six guidance modalities in PCI.
Primary outcome was major adverse cardiovascular events (MACEs), with hazard ratios pooled using a random-effects model.
Subgroup analyses focused on clinical presentation and guidance objectives.
IVUS-guided PCI showed a significantly lower risk of MACEs compared to angiography-guided PCI (HR, 0.69).
Optical coherence tomography-guided PCI also reduced MACEs (HR, 0.75).
Fractional flow reserve-guided PCI was beneficial (HR, 0.81) but not as effective as imaging-guided techniques.
IVUS-guided PCI was more effective than instantaneous wave-free ratio-guided PCI (HR, 0.74).

Cite This Study

Saito et al. (2026) studied this question.

synapsesocial.com/papers/69cb6556e6a8c024954b973d https://doi.org/10.1161/jaha.125.046367

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Comparison of Intravascular Imaging–, Physiology‐, or Angiography‐Guided Approaches for Percutaneous Coronary Intervention: A Systematic Review and Network Meta‐Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of Intravascular Imaging–, Physiology‐, or Angiography‐Guided Approaches for Percutaneous Coronary Intervention: A Systematic Review and Network Meta‐Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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