Analysis of Antidepressant-Related Adverse Events in National and International Literature: A Scoping Review

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Key Points

This review aims to synthesize evidence on adverse events linked to antidepressant use across diverse studies.
Conducted a scoping review to gather evidence on antidepressant safety.
Reviewed national health insurance claims, adverse event reporting, and electronic health records.
Analyzed cohort studies for risk estimates of significant clinical outcomes.
Identified safety signals from spontaneous reporting systems.
Correlated findings from meta-analyses with specific adverse outcomes.
Adverse events varied significantly by antidepressant drug class and individual agents.
Cohort studies linked antidepressant use to risks like cardiovascular events and hyponatremia.
Spontaneous reporting highlighted serious but rare events such as suicide risks and cardiac arrhythmias.
Meta-analyses supported associations between drug classes and specific adverse outcomes.

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Scoping review maps safety profiles of antidepressants, indicating the need for vigilant monitoring in high-risk populations.

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Jeong et al. (2026) studied this question.

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