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The review aims to summarize the properties and applications of silk fibroin in biomedical fields.

April 1, 2026MoleculesOpen Access

Silk Fibroin for Biomedical Applications with Emphasis on Bioimaging, Biosensing and Regenerative Systems: A Review

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This review examines silk fibroin's versatile biomedical applications, indicating its potential for next-generation diagnostics and therapies.

The review aims to summarize the properties and applications of silk fibroin in biomedical fields.
Summarized structural and physicochemical properties of silk fibroin.
Described extraction and regeneration protocols for various material formats.
Outlined functionalization strategies including physical and chemical methods.
Examined specific biomedical applications like bioimaging, biosensing, and tissue engineering.
Silk fibroin exhibits excellent mechanical and thermal properties suitable for biomedical use.
Versatile applications include bioimaging systems using hybrid silk-fluorophore configurations.
Identified silk fibroin's roles in wound dressing and tissue engineering scaffolds.
Discussed challenges like process variability and limitations of blending and cross-linking.

Tomljenovic-Hanic et al. (2026) studied this question.

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This review examines silk fibroin's versatile biomedical applications, indicating its potential for next-generation diagnostics and therapies.