Between 1992 and 2021, the global prevalence of hypertensive heart disease among women of childbearing age increased from 20.09 to 27.94 per 100,000, while mortality and DALY rates generally declined.
Observational
While mortality from hypertensive heart disease among women of childbearing age has declined globally, its prevalence has steadily increased, highlighting the need for targeted cardiovascular prevention in this demographic.
Background: Hypertensive heart disease (HHD) is an important contributor to cardiovascular morbidity among women of childbearing age (WCBA), yet long-term global trends in this population remain insufficiently characterized. We aimed to describe the prevalence, mortality, and disability-adjusted life years (DALYs) of HHD among WCBA at global, regional, and national levels and to assess temporal patterns from 1992 to 2021. Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 study. We estimated numbers and age-standardized rates of prevalence, mortality, and DALYs for women aged 15– 49 years. An age-period-cohort (APC) model was applied to disentangle age, period, and cohort effects on mortality trends. Results: From 1992 to 2021, the global burden of HHD among WCBA exhibited a divergent trend: while the prevalence rate increased steadily from 20.09% to 27.94%, mortality and DALY rates generally declined. In 2021, significant regional disparities existed, with the middle-SDI region recording the highest prevalence, whereas the high-middle SDI region achieved the lowest mortality and DALY rates. APC analyses for mortality further clarified these shifts: period-effect risks declined across most SDI groups but notably increased in high-SDI countries. Similarly, while cohort-effect risks significantly reduced in most regions, high-SDI countries exhibited a distinct pattern of an initial risk rise followed by a subsequent decline. Conclusion: Global HHD trends among WCBA are characterized by rising prevalence alongside declining mortality and DALY rates. Marked disparities persisted across SDI regions, with the highest prevalence in middle-SDI settings and more variable mortality patterns in high-SDI settings. Keywords: hypertensive heart disease, women of childbearing age, global burden of disease, age-period-cohort model
Huang et al. (Sun,) conducted a observational in Hypertensive heart disease. Between 1992 and 2021, the global prevalence of hypertensive heart disease among women of childbearing age increased from 20.09 to 27.94 per 100,000, while mortality and DALY rates generally declined.