Analysis finds low margin to depth of invasion ratios link to worse cancer outcomes in node-negative patients, suggesting treatment need.
Among pN0 OTSCC patients with negative surgical margins (≥1 mm), survival outcomes differed significantly between the high and low MDR groups. Patients with a low MDR had a markedly higher risk of recurrence and poorer cancer-specific survival, suggesting that adjuvant treatment may be warranted for this subgroup.
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Yang et al. (2026) studied this question.
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