Why the study?
How do major bleeding and myocardial infarction compare in their association with the incidence and timing of mortality in patients with non-ST-elevation acute coronary syndromes?
How do major bleeding and myocardial infarction compare in their association with the incidence and timing of mortality in patients with non-ST-elevation acute coronary syndromes?
Major bleeding and myocardial infarction carry a similar overall 1-year mortality risk in NSTE-ACS patients, though MI drives acute short-term risk while bleeding confers a prolonged risk.
Warrants dual monitoring of bleed and MI risks after NSTE-ACS; leaves open whether timed interventions improve survival.
After accounting for baseline predictors of mortality, major bleeds and MI have similar overall strength of association with mortality in the first year after ACS. MI is correlated with a dramatic increase in short-term risk, whereas major bleeding correlates with a more prolonged mortality risk.
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Mehran et al. (2009) studied this question.
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