Key result
Higher atherogenic index of plasma and uric acid-to-creatinine ratio link to late post-ablation AF recurrence.
Why the study?
Do atherogenic index of plasma (AIP) and serum uric acid to creatinine ratio (sUA/CrR) predict late non-valvular AF recurrence after catheter ablation in patients with non-valvular AF?
Cohort (n=401)
No
Do atherogenic index of plasma (AIP) and serum uric acid to creatinine ratio (sUA/CrR) predict late non-valvular AF recurrence after catheter ablation in patients with non-valvular AF?
Atherogenic index of plasma and serum uric acid to creatinine ratio are independent predictors of late atrial fibrillation recurrence after catheter ablation.
Answers are grounded in this paper and cite their sources.
May aid risk stratification for late AF recurrence post-ablation; extends models but leaves open routine adoption pending validation.
BACKGROUND: Atrial fibrillation (AF) is one of the most common clinical arrhythmias, and postoperative recurrence remains a major concern in cardiovascular medicine. However, the predictive value of atherogenic index of plasma (AIP) and serum uric acid to creatinine ratio (sUA/CrR) for late non-valvular AF recurrence after catheter ablation remains unclear. AIMS: This study aimed to investigate the predictive value of AIP and sUA/CrR for late non-valvular AF recurrence after catheter ablation. METHODS: This study included 401 patients with non-valvular AF who were treated at Fujian Medical University Union Hospital between 2018 and 2022. The associations between the sUA/CrR, AIP, and late AF recurrence after catheter ablation were analyzed using univariate and multivariate Cox regression models, as well as Kaplan-Meier survival analysis. Machine learning methods were used to evaluate the predictive performance of the model. SHapley Additive exPlanations (SHAP) was employed to assess the interpretability of the model. In addition, the potential mediating roles of AIP and sUA/CrR in clinical outcomes were explored. RESULTS: Multivariable Cox regression analysis showed that both the AIP (p = 0.006, HR = 3.259, 95% CI: 1.415-7.506) and the sUA/CrR (p = 0.001, HR = 1.188, 95% CI: 1.069-1.321) were independently associated with late AF recurrence after catheter ablation. Mediation analysis revealed a bidirectional mediating effect between AIP and sUA/CrR in their associations with late AF recurrence. SHAP analysis highlighted that both AIP and sUA/CrR are important predictive indicators for AF recurrence after ablation. CONCLUSION: Both AIP and sUA/CrR are positively correlated with late AF recurrence after catheter ablation, exhibiting a bidirectional mediating effect. A clinical prediction model integrating these two indicators may facilitate risk stratification of late AF recurrence after catheter ablation.
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Wang et al. (2026) conducted a cohort in Non-valvular atrial fibrillation (n=401). Atherogenic index of plasma (AIP) and serum uric acid to creatinine ratio (sUA/CrR) was evaluated on Late AF recurrence after catheter ablation (HR 3.259, 95% CI 1.415-7.506, p=0.006). Both atherogenic index of plasma (HR 3.259; 95% CI 1.415-7.506) and serum uric acid to creatinine ratio (HR 1.188; 95% CI 1.069-1.321) were independently associated with late AF recurrence.
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