Acquired Platelet Dysfunction Secondary to Myelodysplastic Neoplasm: Successful Resolution With Neoplasm‐Directed Therapy

Acquired platelet dysfunction has been reported as a complication of hematologic malignancies. Diagnosis and management of platelet dysfunction with a concomitant myeloid disorder can be challenging, and there is a need for real‐world experience reports to help clinicians recognize these entities and manage them accordingly. Herein, we report a case of a 68‐year‐old female patient who was initially diagnosed with acquired platelet dysfunction disease (Glanzmann thrombasthenia [GT] versus alpha‐storage disease) and was found to have myelodysplastic neoplasm (MDS). By giving an MDS‐directed therapy (noncytotoxic dose hypomethylating agent [HMA] + venetoclax), the patient was able to achieve good disease control and a significant improvement of her platelet function disorder.