Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in heart failure with preserved ejection fraction – implications for clinical trials

Fig. 1. Study overview. *Of the 20 patients with newly diagnosed coronary artery disease (CAD), 4 patients had concomitant hypertrophic cardiomyopathy (HCM)

Fig. 2. Examples of typical findings in the ‘new diagnoses’ group. CMR images of: a sub-endocardial, inferolateral myocardial infarction of 25–50% transmurality on LGE; b inferoseptal and inferior perfusion defect consistent with right coronary artery territory ischaemia; c global, concentric perfusion defect consistent with microvascular dysfunction; d horizontal long axis cine demonstrating asymmetrical septal hypertrophy in HCM; E) constrictive pericarditis with circumferential pericardial hyperenhancement on LGE; white arrows point towards pathology; LGE = late gadolinium enhancement imaging

Fig. 3. Characteristics of newly diagnosed myocardial infarction according to coronary arterial distribution and transmurality. LAD = left anterior descending artery; RCA = right coronary artery; LCX = left circumflex artery; % transmurality of MI is illustrated as 1–25, 26–50, 51–75, 76–100; RWMA = regional wall motion abnormality

Fig. 4. Kaplan Meier analysis for the composite endpoint of death and/or hospitalization with heart failure. Nil