Population
Rats with experimental pulmonary arterial hypertension and mild or severe right ventricular (RV) dysfunction
Design
Preclinical
Authors
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Animal model data require human validation before any clinical application; extends mechanistic insights into severity-dependent RV stiffness.
The mechanisms of right ventricular myocardial stiffness in pulmonary arterial hypertension evolve with disease severity, shifting from purely myofibril-driven in mild dysfunction to a combination of myofibril and fibrosis-driven in severe dysfunction.
Rain et al. (2016) studied this question.
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