Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates

Figures

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  Fig. 1. Experimental setup of CGM and DOT acquisition in the NICU. (a) Exemplary preterm neonate with the CGM inserted at the thigh and the DOT cap. (b) Source (in red) and detector (in blue) locations, with annotations of the main EEG 10 to 20 landmark positions for reference. The detectors are approximately placed on F1, F2, CCP5, C1, C2, CCP6, P1, and P2, and the sources are approximately placed on FC3, FCz, FC4, CP3, CPz, CP4, PO5h, and PO6h. (c) Histogram showing the source detector separations of all measurement channels.

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  Fig. 2. (a) Example Jacobian based upon good channels, for patient 25 (GA model was 31 weeks), during the best 5-min window for the first tfFC analysis. The coverage threshold was 0.0082 ΔIΔμa−1. (b) Nine EEG ROIs for this patient.

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  Fig. 3. Spider plot of the glucose metrics computed for the 12 patients in the tfFC subgroup. Each color line denotes a patient, and each vertex of the spider plot represents a different metric. TIR %, percentage of time spent within the euglycemic range; TOR %, percentage of time spent outside the euglycemic range; TBR %, percentage of time spent below the euglycemic range; TAR %, percentage of time spent above the euglycemic range.

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  Fig. 4. tfFC for HbO and HbR in the first and last 5-min time windows. (a) and (b) On the left, the average R value across all subjects for each ROI pair for HbO in the first time window (a) and last time window (b). The graph on the right shows the fdr corrected p-values of the Z-scores computed across patients. (c) and (d) Same as panels (a) and (b) but for HbR.

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  Fig. 5. Statistically significant correlation between changes in tfFC for HbR and the SD glucose metric. On the right, a scatter plot showing the correlation is presented. Each dot represents a patient.

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  Fig. 6. Statistically significant correlation between changes in tfFC for HbR and the MAX glucose metric. On the right, a scatter plot showing the correlation is presented. Each dot represents a patient.