Harmonization of IGF1 immunoassays toward a higher-order LC-MS/MS reference anchor

Egwm Lentjes; M.S Pratt; IP Kema; Martijn van Faassen; R.E.A. Musson; M.J.Vos

doi:10.1530/ec-25-0805

April 1, 2026Endocrine ConnectionsOpen Access

Harmonization of IGF1 immunoassays toward a higher-order LC-MS/MS reference anchor

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Key Points

The aim is to achieve harmonization of IGF1 immunoassays using a higher-order LC-MS/MS reference.
Utilized matrix-matched serum reference materials (RMs) for value assignment.
Applied a higher-order LC-MS/MS analytical procedure for consistency.
Focused on reducing bias and variability among different immunoassays.
Significant reduction in inter-assay bias was observed.
Variability among IGF1 immunoassays decreased substantially.
A robust foundation for cross-platform interpretation was established.

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Abstract

Matrix-matched, commutable serum RMs value-assigned by a higher-order LC-MS/MS procedure enable substantial reduction of inter-assay bias and variability among IGF1 immunoassays. Harmonization toward a higher-order analytical anchor is achievable in routine practice and provides a robust foundation for consistent cross-platform interpretation.

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Cite This Study

Lentjes et al. (2026) studied this question.

synapsesocial.com/papers/69d0ae68659487ece0fa4671 https://doi.org/10.1530/ec-25-0805

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Harmonization of IGF1 immunoassays toward a higher-order LC-MS/MS reference anchor

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Abstract

Discussion

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Harmonization of IGF1 immunoassays toward a higher-order LC-MS/MS reference anchor

Key Points

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Abstract

Discussion

Cite This Study

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