What question did this study set out to answer?

The aim is to optimize the extraction of bioactive compounds from Ballota limbata using sustainable methods.

April 4, 2026Scientific ReportsOpen Access

Artificial neural networks (ANN) and response surface methodology (RSM) for optimizing antioxidant and α-amylase inhibitory compound extraction from Ballota limbata

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Authors

NNamraForman Christian College HIHaroon IftikharForman Christian College AAAlev Yüksel AydarManisa Celal Bayar University

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Implication

Demonstrates the optimization of bioactive compound extraction in a medicinal plant, suggesting microwave-assisted methods are efficient and eco-friendly.

Key Points

The aim is to optimize the extraction of bioactive compounds from Ballota limbata using sustainable methods.
Compared microwave-assisted extraction (MA) and conventional heat-assisted extraction (HA).
Utilized 70% hydro-ethanol solvent and optimized processes with response surface methodology (RSM).
Applied a Box-Behnken design within an artificial neural network (ANN) framework to analyze extraction efficiency.
Microwave-assisted extraction yielded lower total phenolic content (3.27 mg GAE/g) than heat-assisted extraction (3.85 mg GAE/g).
Heat-assisted extraction (86.22%) had higher alpha-amylase inhibitory activity compared to microwave-assisted extraction (60.99%).
ANN demonstrated superior predictive accuracy with higher R2 and lower error metrics compared to RSM.

Cite This Study

Namra et al. (2026) studied this question.

synapsesocial.com/papers/69d0ae94659487ece0fa491a https://doi.org/10.1038/s41598-026-37738-x

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Implication

Demonstrates the optimization of bioactive compound extraction in a medicinal plant, suggesting microwave-assisted methods are efficient and eco-friendly.

Artificial neural networks (ANN) and response surface methodology (RSM) for optimizing antioxidant and α-amylase inhibitory compound extraction from Ballota limbata

Discussion

Member takes

Implication

Key Points

Cite This Study

Artificial neural networks (ANN) and response surface methodology (RSM) for optimizing antioxidant and α-amylase inhibitory compound extraction from Ballota limbata

Discussion

Member takes

Implication

Key Points

Cite This Study

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