What question did this study set out to answer?

This research aims to characterize the presentation, diagnosis, and outcomes of cardiac implantable electronic device lead perforation over 25 years.

April 4, 2026Journal of Clinical MedicineOpen Access

Cardiac Implantable Electronic Device Lead Perforation: A 25-Year Single-Center Experience

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Why the study?

As global CIED implantations increase, understanding the clinical spectrum, diagnostic strategies, and optimal management of rare but potentially catastrophic lead perforations is essential.

Population

32 patients diagnosed with CIED lead perforation at a high-volume center

Design

Single-center retrospective analysis

Authors

SASameer Al-MaisarySaarland University MKMatthias KarckHeidelberg University MGMario Jesus Guzman-RuvalcabaHeidelberg University

Discussion

Member takes

Implication

Immediate surgical backup required for unstable CIED lead perforation; supports transvenous removal in stable patients.

Key Points

This research aims to characterize the presentation, diagnosis, and outcomes of cardiac implantable electronic device lead perforation over 25 years.
Conducted a retrospective analysis of 32 patients diagnosed with lead perforation from 2000 to 2025.
Classified perforations based on timing: acute, subacute, and chronic.
Collected data on demographics, comorbidities, imaging modalities, and procedural interventions.
Most common presentation was subacute (59.3%), followed by acute (28.1%) and chronic (12.5%).
Computed Tomography confirmed diagnosis in 31.3% of cases, especially with stable lead parameters.
71.9% of patients were successfully treated with transvenous lead removal; high-risk cases required surgical interventions.

Structured PICO

Population

32 patients diagnosed with cardiac implantable electronic device (CIED) lead perforation between 2000 and 2025 at a single high-volume center. Mean age 76.0 ± 11.7 years, mean BMI 25.5 ± 3.4 kg/m2.

Intervention

Management of CIED lead perforation (percutaneous transvenous lead removal via simple traction for stable patients vs. surgical intervention for hemodynamically unstable patients).

Outcome

Clinical presentation, diagnostic strategies, and outcomes (including survival to discharge and length of hospital stay).

CIED lead perforation often presents subacutely and can be safely managed with transvenous lead removal in stable patients, though immediate surgical backup is vital for those with hemodynamic instability.

Cite This Study

Al-Maisary et al. (2026) studied this question.

synapsesocial.com/papers/69d0aeb9659487ece0fa49f7 https://doi.org/10.3390/jcm15072705

Topics

Cardiac device therapy

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Cardiac Implantable Electronic Device Lead Perforation: A 25-Year Single-Center Experience

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cardiac Implantable Electronic Device Lead Perforation: A 25-Year Single-Center Experience

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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