Animal model study investigates wound healing and antimicrobial benefits of silver nanoparticles and hyaluronic acid, suggesting combined treatment is superior.
Key Points
This research aims to explore the wound healing and antimicrobial effects of silver nanoparticles and hyaluronic acid in animal models.
Twenty rabbits divided into five groups
Induced skin wounds contaminated with multidrug-resistant Pseudomonas aeruginosa
Treated with silver nanoparticle ointment, hyaluronic acid ointment, or their combination for 15 days
Evaluated healing process using gross and histopathological findings
Compared inflammation and regeneration scores across groups.
All treated groups showed improved wound healing compared to the induction group.
The 1% silver nanoparticle group had greater improvement in reducing inflammation compared to the hyaluronic acid group.
Hyaluronic acid group exhibited better epidermal regeneration than the induction group.
The combination-treated group showed the fastest wound healing and lowest inflammation score, along with high scores for skin regeneration and collagen deposition.