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April 4, 2026Journal of Nuclear Medicine

Translation of Intraoperative Molecular Imaging for Clinical Use

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Authors

LRLauren RosenblumAPArjun PantCYCatherine Yip

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Overview

Review highlights integration of intraoperative molecular imaging in surgery, suggesting enhanced outcomes.

Key Points

  • This review focuses on the advancement and clinical application of intraoperative molecular imaging (IMI).
  • Reviewed clinical trials supporting IMI tracers in surgery.
  • Discussed types of IMI tracers, including fluorescent, radioactive, and dual-labeled.
  • Explored advancements in imaging devices for enhanced surgical applications.
  • IMI improves visualization and delineation of tissues during surgery.
  • Integration of novel activatable tracers shows promise in targeting tumor microenvironments.
  • IMI has received FDA approval for various tracers enhancing surgical outcomes.

Cite This Study

Rosenblum et al. (2026) studied this question.

synapsesocial.com/papers/69d0aff2659487ece0fa615ahttps://doi.org/10.2967/jnumed.124.268773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intraoperative Molecular Imaging in Thoracic Oncology: Expanding the Observable Disease Space2026
  2. 2Precision at the Margin: Innovations and Challenges in Intraoperative Molecular Imaging for Thoracic Surgery2026
  3. 3Detection properties of indium-111 and IRDye800CW for intraoperative molecular imaging use across tissue phantom models2024 · 2 citations
  4. 4VGT-309: A tumor-targeted near-infrared imaging agent for intraoperative cancer detection2024
  5. 5Editorial: Applications of fluorescence in surgery and diagnostics, volume II: evolution and breakthroughs2026