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July 12, 2026CancersOpen Access

Intraoperative Molecular Imaging in Thoracic Oncology: Expanding the Observable Disease Space

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Authors

EMEliana MarosticaSSSunil Singhal

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Overview

Narrative review highlights intraoperative molecular imaging's impact on thoracic oncology, suggesting potential improvements in disease localization.

Key Points

  • This review aims to summarize the technical foundations, clinical applications, and future directions of intraoperative molecular imaging in thoracic oncology.
  • Performed a narrative review to integrate mechanistic, translational, and clinical evidence about intraoperative molecular imaging.
  • Discussed various imaging agents and their applications in thoracic oncology.
  • Evaluated evidence from prospective studies and multicenter trials than a single clinical question.
  • Intraoperative molecular imaging improved localization of nonpalpable lesions and identified occult malignancies.
  • Enhanced margin assessment during surgery, leading to altered surgical management in several cases.
  • Phase 2 and 3 studies of folate receptor-targeted imaging revealed significant findings in many patients, detecting lesions missed by traditional methods.

Cite This Study

Marostica et al. (2026) studied this question.

synapsesocial.com/papers/6a5333754f7abc118adee016https://doi.org/10.3390/cancers18142220
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Precision at the Margin: Innovations and Challenges in Intraoperative Molecular Imaging for Thoracic Surgery2026
  2. 2Translation of Intraoperative Molecular Imaging for Clinical Use2026 · 3 citations
  3. 3Intraoperative Nodule Localization in Non-Small-Cell Lung Cancer: Existing and Emerging Techniques2026 · 2 citations
  4. 4A review on the use of radionuclide imaging techniques to detect margin positivity in intraoperative specimens during breast-conserving surgery2025
  5. 5VGT-309: A tumor-targeted near-infrared imaging agent for intraoperative cancer detection2024