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June 12, 2026Journal of Clinical MedicineOpen Access

Precision at the Margin: Innovations and Challenges in Intraoperative Molecular Imaging for Thoracic Surgery

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Authors

EREmily P. RabinovichLMLinda W. Martin

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Overview

Randomized trial evaluates intraoperative imaging effectiveness in thoracic surgery, highlighting challenges and advancements.

Key Points

  • The aim is to assess the effectiveness of intraoperative molecular imaging in improving tumor localization and margin assessment during thoracic surgery.
  • Assessment of intraoperative molecular imaging technology using near-infrared fluorophores for tumor localization during pulmonary resection.
  • Identification of challenges in workflow integration and optical depth constraints associated with imaging.
  • Analysis of clinical applications in nodal evaluation and margin adequacy.
  • Intraoperative molecular imaging demonstrates improved localization of small or nonpalpable pulmonary nodules and enhanced margin assessment.
  • Significant barriers include biologic variability and false-positive results in inflammatory tissues.
  • Future directions include quantitative fluorescence interpretation and standardized reporting to enhance clinical implementation.

Cite This Study

Rabinovich et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2c18101cf8926f01a31https://doi.org/10.3390/jcm15124493
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intraoperative Molecular Imaging in Thoracic Oncology: Expanding the Observable Disease Space2026
  2. 2Translation of Intraoperative Molecular Imaging for Clinical Use2026 · 3 citations
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  4. 4Intraoperative Nodule Localization in Non-Small-Cell Lung Cancer: Existing and Emerging Techniques2026 · 2 citations
  5. 5A review on the use of radionuclide imaging techniques to detect margin positivity in intraoperative specimens during breast-conserving surgery2025