Clinical significance of chemosensitivity in chronic heart failure: influence on neurohormonal derangement, Cheyne–Stokes respiration and arrhythmias
Why the study?
Is enhanced chemosensitivity associated with neurohormonal derangement, Cheyne-Stokes respiration, and arrhythmias in patients with chronic heart failure?
Population
Patients with chronic heart failure (mean age 66, mean LVEF 31%)
Comparison
Enhanced chemosensitivity to hypoxia and… vs Normal chemosensitivity
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in chronic HF; prospective studies needed before considering chemosensitivity as therapeutic target.
Structured PICO
Is enhanced chemosensitivity associated with neurohormonal derangement, Cheyne-Stokes respiration, and arrhythmias in patients with chronic heart failure?
P
Population
Patients with chronic heart failure (mean age 66, mean LVEF 31%)
I
Intervention
Enhanced chemosensitivity to hypoxia and hypercapnia
C
Comparator
Normal chemosensitivity
O
Outcome
Neurohormonal balance, breathing pattern, response to exercise, and arrhythmic profilesurrogate
Enhanced chemosensitivity in chronic heart failure is associated with neurohormonal impairment, Cheyne-Stokes respiration, and increased arrhythmias.
Cite This Study
Giannoni et al. (2008) studied this question.