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April 5, 2026Cancer Research

Ferroptosis-Related LncRNA-MiRNA-MRNA Signature Predicts Prognosis in Endometrial Cancer

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Authors

HMHikaru MurakamiUniversity of Hawaiʻi at MānoaJWJunlong WangUniversity of Hawaiʻi at MānoaHYHerbert Yu

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Implication

This investigation demonstrates a prognostic model for predicting outcomes in endometrial cancer, suggesting implications for immunotherapy strategies.

Key Points

  • The study aims to identify ferroptosis-related gene interactions and construct a prognostic model for endometrial cancer (EC).
  • Analyzed tumor transcriptomes and clinical data from 544 EC patients using TCGA.
  • Identified ferroptosis-related coding genes through FerrDb.
  • Constructed a prognostic model using univariate, multivariate, and Lasso Cox regression analyses.
  • Grouped patients into high- and low-risk based on risk scores from gene expression.
  • Used Kaplan-Meier analysis and ROC curves to evaluate prognostic value.
  • Identified sixteen prognostic markers (10 lncRNAs, 2 miRNAs, and 4 mRNAs).
  • High-risk patients had a significantly worse overall survival (P < 0.001).
  • ROC curve AUC values were 0.731, 0.749, and 0.768 for 1, 3, and 5-year survival.
  • The model outperformed other clinical factors in predicting prognosis.
  • GSEA showed high-risk patients had lower antitumor immunity and enriched cancer-related pathways.

Cite This Study

Murakami et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcc0a79560c99a0a2685https://doi.org/10.1158/1538-7445.am2026-1194
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated Identification and Immunotherapy Response Analysis of the Prognostic Signature Associated With m6A , Cuproptosis‐Related, Ferroptosis‐Related lncRNA in Endometrial Cancer2024 · 3 citations
  2. 2A novel ferroptosis-related microRNAs signature for predicting prognosis in endometrial cancer: An observational study2025
  3. 3A ferroptosis-related signature predicts the clinical diagnosis and prognosis, and associates with the immune microenvironment of lung cancer2024 · 4 citations
  4. 4Integrated analysis of a competing endogenous RNA network reveals a ferroptosis-related 6-lncRNA prognostic signature in clear cell renal cell carcinoma2024 · 11 citations
  5. 5Ferroptosis-related lncRNA signature predicts prognosis and immune microenvironment remodeling in laryngeal squamous cell carcinoma2026