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April 5, 2026Head & Neck

Significance of Preoperative Imaging‐Detected Extranodal Extension in Pathological Extranodal Extension‐Positive Head and Neck Squamous Cell Carcinoma Treated With Postoperative Chemoradiotherapy

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This research aims to determine the prognostic value of preoperative imaging-detected extranodal extension in patients with pathological extranodal extension-positive HNSCC.
Retrospective analysis of patients with pathological extranodal extension-positive HNSCC treated with postoperative chemoradiotherapy.
Reclassification of imaging-detected and pathological extranodal extension using standardized criteria.
Survival analysis conducted using Kaplan–Meier and Cox proportional hazards models.
Patients with imaging-detected extranodal extension grades 2–3 showed significantly worse recurrence-free survival (RFS) compared to grades 0–1 (68.5% vs. 31.5%).
Three-year overall survival (OS) was also poorer for grades 2–3 compared to grades 0–1 (85.0% vs. 63.2%).
Multivariable analysis identified imaging-detected extranodal extension as the only independent prognostic factor for both RFS and OS.

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This analysis evaluates the prognostic significance of imaging-detected extranodal extension in patients with head and neck squamous cell carcinoma, indicating its impact on survival rates.

Cite This Study

Hoshi et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd29a79560c99a0a3004 https://doi.org/10.1002/hed.70256

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Implication

This analysis evaluates the prognostic significance of imaging-detected extranodal extension in patients with head and neck squamous cell carcinoma, indicating its impact on survival rates.

Significance of Preoperative Imaging‐Detected Extranodal Extension in Pathological Extranodal Extension‐Positive Head and Neck Squamous Cell Carcinoma Treated With Postoperative Chemoradiotherapy

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Discussion

Implication

Cite This Study

Significance of Preoperative Imaging‐Detected Extranodal Extension in Pathological Extranodal Extension‐Positive Head and Neck Squamous Cell Carcinoma Treated With Postoperative Chemoradiotherapy

Key Points

Discussion

Implication

Cite This Study

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