What question did this study set out to answer?

This research aims to assess the prognostic significance of imaging-detected extranodal extension in patients with pathological ENE-negative head and neck squamous cell carcinoma.

May 29, 2026Journal of Clinical Oncology

Prognostic significance of imaging-detected extranodal extension (iENE) in pathological ENE-negative head and neck squamous cell carcinoma.

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Authors

RKRyo KubokiNational Cancer Center Hospital East TETomohiro EnokidaNational Cancer Center Hospital East HKHirofumi KunoNational Cancer Center Hospital East

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Implication

Randomized trial evaluates the impact of imaging-detected extranodal extension on survival in HNSCC, suggesting its prognostic value.

Key Points

This research aims to assess the prognostic significance of imaging-detected extranodal extension in patients with pathological ENE-negative head and neck squamous cell carcinoma.
Retrospective review of patients with HNSCC treated between 2012 and 2021.
Eligible patients had confirmed lymph node metastasis and negative surgical margins without evidence of pathological ENE.
iENE status assessed by radiologists, with survival outcomes analyzed.
iENE-positive patients had a shorter 5-year event-free survival (33.1% vs. 55.4%; HR 1.69; p=0.029).
Inferior overall survival was also observed for iENE-positive patients (5-year: 68.7% vs. 80.4%).
iENE positivity was independently associated with poorer event-free survival alongside ECOG Performance Status ≥1 and lower serum albumin.

Cite This Study

Kuboki et al. (2026) studied this question.

synapsesocial.com/papers/6a192d7efab5b468c4416691 https://doi.org/10.1200/jco.2026.44.16_suppl.6079

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Prognostic significance of imaging-detected extranodal extension (iENE) in pathological ENE-negative head and neck squamous cell carcinoma.

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Implication

Key Points

Cite This Study

Prognostic significance of imaging-detected extranodal extension (iENE) in pathological ENE-negative head and neck squamous cell carcinoma.

Discussion

Member takes

Implication

Key Points

Cite This Study

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