What question did this study set out to answer?

This research aims to explore the role of superoxide and angiotensin II in sympathetic nervous system activation during chronic heart failure.

October 28, 2004Circulation Research

Superoxide Mediates Sympathoexcitation in Heart Failure

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Why the study?

Does central Angiotensin II activate sympathetic outflow by stimulation of NAD(P)H oxidase and reactive oxygen species in the chronic heart failure state?

Population

Male New Zealand White rabbits with chronic heart failure induced by chronic ventricular tachycardia, and…

Comparison

Intracerebroventricular infusions of Angiotensin… vs Sham rabbits and baseline control state

Design

Preclinical

Authors

LGLie GaoHeart Failure & Transplant WWWei WangGeneral Cardiology YLYu‐Long LiBeijing University of Chinese Medicine

Discussion

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Implication

Central Ang II augments sympathetic outflow via ROS in experimental CHF; hypothesis-generating for human sympathoexcitation therapies.

Key Points

This research aims to explore the role of superoxide and angiotensin II in sympathetic nervous system activation during chronic heart failure.
Chronic heart failure induced in male New Zealand White rabbits by ventricular tachycardia.
Radio telemetry and intracerebroventricular infusions were utilized to measure sympathetic outflow (RSNA).
The effects of angiotensin II, losartan, tempol, and apocynin on RSNA were assessed.
Intracerebroventricular angiotensin II increased RSNA by 193.6+/-11.9% in CHF rabbits (P<0.01 vs sham).
Intracerebroventricular administration of losartan and tempol reduced resting RSNA significantly in CHF rabbits but not sham rabbits.
NADPH-dependent superoxide production was increased 2.9-fold in the RVLM of CHF rabbits compared to sham.

Structured PICO

Does central Angiotensin II activate sympathetic outflow by stimulation of NAD(P)H oxidase and reactive oxygen species in the chronic heart failure state?

Population

Male New Zealand White rabbits with chronic heart failure (CHF) induced by chronic ventricular tachycardia, and sham rabbits

Intervention

Intracerebroventricular infusions of Angiotensin II, losartan, tempol, apocynin, or diethyldithio-carbamic acid

Comparator

Sham rabbits and baseline control state

Outcome

Renal sympathetic nerve activity (RSNA) as a direct measure of sympathetic outflowsurrogate

Central Angiotensin II increases sympathetic nerve activity in heart failure via NAD(P)H oxidase-derived reactive oxygen species, highlighting a mechanism for sympathoexcitation in this condition.

Cite This Study

Gao et al. (2004) studied this question.

synapsesocial.com/papers/69d5312b5ba246d8dea6700a https://doi.org/10.1161/01.res.0000146676.04359.64

Topics

Heart failure HFrEF treatment Ventricular arrhythmias

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Superoxide Mediates Sympathoexcitation in Heart Failure

Discussion

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Implication

Key Points

Structured PICO

Cite This Study

Topics

Superoxide Mediates Sympathoexcitation in Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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