Why the study?
Does central administration of superoxide dismutase reduce neuronal activation and sympathetic hyperactivity in mice with MI-induced heart failure?
Population
Adult C57BL/6 mice with myocardial infarction-induced heart failure (via left coronary artery ligation)
Comparison
Intracerebroventricular injection of an… vs Saline or a control vector, and sham-operated mice
Design
Preclinical
Follow-up
2 and 4 weeks
Authors
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Hypothesis-generating for central ROS targeting in post-MI sympathetic activation; clinical translation untested.
Does central administration of superoxide dismutase reduce neuronal activation and sympathetic hyperactivity in mice with MI-induced heart failure?
Central administration of superoxide dismutase attenuates neuronal activation and sympathetic hyperactivity in a mouse model of MI-induced heart failure, suggesting brain oxygen radicals as a potential therapeutic target.
Lindley et al. (2003) studied this question.
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