Adiponectin improves the redox state in human vessels by restoring eNOS coupling, revealing a novel interaction between the vascular wall and perivascular adipose tissue.
May support adiponectin as vascular redox modulator; animal data leave open translation to human cardiovascular therapy.
We demonstrate for the first time that adiponectin improves the redox state in human vessels by restoring eNOS coupling, and we identify a novel role of vascular oxidative stress in the regulation of adiponectin expression in human perivascular adipose tissue.
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Margaritis et al. (2013) studied this question.