Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction
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Discussion
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Implication
Randomized trial demonstrates sudden cardiac death risk linked to midwall late gadolinium enhancement in dilated cardiomyopathy, highlighting critical targets for risk stratification.
Key Points
- To assess the relationship between midwall late gadolinium enhancement and sudden cardiac death in patients with dilated cardiomyopathy presenting with mild to moderate left ventricular systolic dysfunction.
- Conducted a registered clinical evaluation (NCT00930735) in patients diagnosed with dilated cardiomyopathy and mild-to-moderate left ventricular systolic dysfunction.
- Assessed midwall fibrosis and myocardial scarring using cardiovascular magnetic resonance with late gadolinium enhancement to monitor subsequent arrhythmic risk and sudden cardiac death.
- Midwall late gadolinium enhancement strongly correlates with increased incidence of sudden cardiac death and sustained ventricular arrhythmias.
- Risk of sudden cardiac death was markedly elevated in the presence of midwall scarring regardless of only mild or moderate reductions in left ventricular systolic function.
Cite This Study
Halliday et al. (2017) studied this question.