Key result
Midwall LGE in non-ischemic DCM is linked to higher end-diastolic elastance and impaired ventriculoarterial coupling.
Why the study?
Is the midwall late gadolinium enhancement (LGE) pattern associated with increased ventricular stiffness and impaired ventriculoarterial coupling in patients with non-ischaemic dilated cardiomyopathy?
Observational (n=49)
Is the midwall late gadolinium enhancement (LGE) pattern associated with increased ventricular stiffness and impaired ventriculoarterial coupling in patients with non-ischaemic dilated cardiomyopathy?
p-value: p=0.006
In patients with advanced non-ischaemic dilated cardiomyopathy, the presence of midwall LGE on CMR is associated with greater ventricular stiffness and impaired ventriculoarterial coupling.
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Associates midwall LGE with greater stiffness and impaired coupling in non-ischaemic cardiomyopathy; hypothesis-generating for prognostic utility.
Choi et al. (2009) conducted an observational in Advanced non-ischaemic dilated cardiomyopathy (n=49). Midwall late gadolinium enhancement (LGE) vs. Non-LGE and non-midwall LGE was evaluated on Ventricular elastic properties and performance (end-diastolic elastance, arterial elastance, and dyssynchrony indices) (p=0.006). Midwall LGE in non-ischaemic DCM was associated with higher end-diastolic elastance (P=0.008), impaired ventriculoarterial coupling (P=0.006), and lower LV systolic velocity (P=0.025).
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