Does viral gene transfer of Bcl-2 protect against chronic postischemic heart failure?
Viral gene transfer of Bcl-2 preserves LV function and reduces ventricular remodeling at 6 weeks in a postischemic heart failure model.
Gene transfer of Bcl-2 preserves LV function after ischemia despite the absence of an observed acute protective effect. The benefit at 6 weeks is postulated to result from a Bcl-2-mediated reduction in apoptosis and ventricular remodeling. Adeno-Bcl-2 administration offers a potential strategy to protect the heart from late postischemic heart failure.
Chatterjee et al. (Tue,) studied this question.