Relationship Between Maximal Left Ventricular Wall Thickness and Sudden Cardiac Death in Childhood Onset Hypertrophic Cardiomyopathy

Figure 1.. The presence of additional clinical risk factors by severity of left ventricular hypertrophy. Additional risk factors include unexplained syncope, nonsustained ventricular tachycardia, left atrial dilatation, and family history of sudden cardiac death.

Figure 2.. Kaplan-Meier survival curves by degree of left ventricular hypertrophy. A, major arrhythmic cardiac event or (B) all-cause mortality or cardiac transplantation. MLVWT indicates maximal left ventricular wall thickness.

Figure 3.. Relationship of estimated 5-y risk of sudden cardiac death (SCD) to maximal wall thickness and the presence or absence of additional clinical risk factors. A, The presence or absence of family history of SCD. B, The presence or absence of unexplained syncope. C, The presence or absence of nonsustained ventricular tachycardia (NSVT). D, All possible combinations of NSVT and unexplained syncope keeping continuous risk factors constant to the cohort mean: maximal left ventricular outflow tract gradient and left atrial diameter Z score. In all cases, the risk of SCD increases up to a point, and once a plateau is reached, the risk declines. MWT indicates maximal wall thickness.