Key result
Extreme left ventricular hypertrophy (MWT ≥35 mm) did not increase the risk of sudden cardiac death compared to MWT ≤14 mm (HR 0.22; 95% CI 0.03-1.65), revealing an inverted U-shaped relationship.
Why the study?
Does extreme maximal left ventricular wall thickness (≥35 mm) increase the risk of sudden cardiac death compared to mild hypertrophy (≤14 mm) in adults with hypertrophic cardiomyopathy?
Cohort (n=3,673)
Yes
Does extreme maximal left ventricular wall thickness (≥35 mm) increase the risk of sudden cardiac death compared to mild hypertrophy (≤14 mm) in adults with hypertrophic cardiomyopathy?
Effect estimate: HR 0.22 (95% CI 0.03-1.65)
The risk of sudden cardiac death in hypertrophic cardiomyopathy has an inverted U-shaped relationship with maximal wall thickness, indicating that extreme hypertrophy (≥35 mm) does not linearly increase SCD risk and should not solely guide ICD implantation.
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Extreme MWT was not linked to higher SCD risk in HCM; hypothesis-generating for inverted U-shaped relationship and ICD criteria.
O’Mahony et al. (2016) conducted a cohort in Hypertrophic cardiomyopathy (n=3,673). Maximal left ventricular wall thickness ≥35 mm vs. Maximal left ventricular wall thickness ≤14 mm was evaluated on Sudden cardiac death (HR 0.22, 95% CI 0.03-1.65). Extreme left ventricular hypertrophy (MWT ≥35 mm) did not increase the risk of sudden cardiac death compared to MWT ≤14 mm (HR 0.22; 95% CI 0.03-1.65), revealing an inverted U-shaped relationship.
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