Why the study?
Does metoprolol reduce LVOT obstruction and improve symptoms in patients with obstructive hypertrophic cardiomyopathy?
Does metoprolol reduce LVOT obstruction and improve symptoms in patients with obstructive hypertrophic cardiomyopathy?
Metoprolol effectively reduces LVOT obstruction and improves symptoms and quality of life in patients with obstructive hypertrophic cardiomyopathy.
Supports metoprolol for symptom relief in obstructive HCM; provides RCT confirmation amid prior equivocal data.
Compared with placebo, metoprolol reduced LVOT obstruction at rest and during exercise, provided symptom relief, and improved quality of life in patients with obstructive HCM. Maximum exercise capacity remained unchanged. (The Effect of Metoprolol in Patients with Hypertrophic Obstructive Cardiomyopathy [TEMPO]; NCT03532802).
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Dybro et al. (2021) studied this question.
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