What question did this study set out to answer?

To assess the efficacy of metoprolol compared with placebo in reducing left ventricular outflow tract (LVOT) obstruction and relieving symptoms in patients with obstructive hypertrophic cardiomyopathy.

December 1, 2021Journal of the American College of CardiologyOpen Access

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy

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Why the study?

Does metoprolol reduce LVOT obstruction and improve symptoms in patients with obstructive hypertrophic cardiomyopathy?

Key Points

To assess the efficacy of metoprolol compared with placebo in reducing left ventricular outflow tract (LVOT) obstruction and relieving symptoms in patients with obstructive hypertrophic cardiomyopathy.
Randomized, placebo-controlled clinical trial (TEMPO; NCT03532802) evaluating metoprolol versus placebo in patients diagnosed with obstructive hypertrophic cardiomyopathy.
Evaluated left ventricular outflow tract (LVOT) obstruction at rest and during exercise, symptom severity, health-related quality of life, and maximum exercise capacity.
Metoprolol significantly reduced LVOT obstruction compared with placebo both at rest and during exercise.
Treatment provided meaningful symptom relief and improved patient quality of life, though maximum exercise capacity remained unchanged.

Structured PICO

Does metoprolol reduce LVOT obstruction and improve symptoms in patients with obstructive hypertrophic cardiomyopathy?

Population

Patients with obstructive hypertrophic cardiomyopathy (HCM)

Intervention

Metoprolol

Comparator

Placebo

Outcome

LVOT obstruction at rest and during exercisesurrogate

Metoprolol effectively reduces LVOT obstruction and improves symptoms and quality of life in patients with obstructive hypertrophic cardiomyopathy.

Discussion

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Implication

Supports metoprolol for symptom relief in obstructive HCM; provides RCT confirmation amid prior equivocal data.

Cite This Study

Dybro et al. (2021) studied this question.

synapsesocial.com/papers/69d56df075589c71d767d1f8 https://doi.org/10.1016/j.jacc.2021.07.065

Topics

Hypertrophic cardiomyopathy

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Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider