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April 15, 1995Circulation

Electrophysiological Effects of Flecainide on Anisotropic Conduction and Reentry in Infarcted Canine Hearts

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Why the study?

Does flecainide prevent reentrant tachycardia in infarcted canine hearts?

Population

Canine hearts with healing infarcts

Design

Preclinical

Authors

JCJames CoromilasElectrophysiologyASAdam E. SaltmanUniversity of TorontoBWBernd WaldeckerWalmart (United States)

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Implication

Flecainide may promote reentry in infarct models; leaves open net effects on clinical ventricular arrhythmias.

Key Points

  • This research aims to investigate how flecainide affects conduction patterns and reentrant circuits in infarcted hearts.
  • Examined the effects of flecainide on conduction in longitudinal and transverse directions
  • Analyzed reentry occurrence in healing myocardial infarcts
  • Utilized canine heart models for electrophysiological assessment
  • Flecainide slows conduction in both longitudinal and transverse directions
  • Sustained reentry occurs more easily with flecainide
  • Flecainide does not block conduction in key areas of reentrant circuits, allowing continued tachycardia

Structured PICO

Does flecainide prevent reentrant tachycardia in infarcted canine hearts?

P
Population
Canine hearts with healing infarcts
I
Intervention
Flecainide
O
Outcome
Anisotropic conduction and reentrysurrogate

Flecainide facilitates sustained reentry and fails to prevent reentrant tachycardia in infarcted canine hearts by slowing conduction without causing block in crucial reentrant circuits.

Cite This Study

Coromilas et al. (1995) studied this question.

synapsesocial.com/papers/69d56e1d75589c71d767d3dahttps://doi.org/10.1161/01.cir.91.8.2245

Topics

Ventricular arrhythmias
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Flecainide and D-Sotalol on Myocardial Conduction and Refractoriness1993 · 19 citations
  2. 2Mapping of ventricular tachycardia induced by programmed stimulation in canine preparations of myocardial infarction.1984 · 66 citations
  3. 3Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification1983 · 277 citations
  4. 4Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry?1993 · 242 citations
  5. 5Reentrant Circuits and the Effects of Heptanol in a Rabbit Model of Infarction with a Uniform Anisotropic Epicardial Border Zone1993 · 18 citations