Why the study?
Does flecainide facilitate reentrant arrhythmias in a dog model of subacute myocardial infarction?
Does flecainide facilitate reentrant arrhythmias in a dog model of subacute myocardial infarction?
Flecainide facilitates reentrant arrhythmias in subacute myocardial infarction by causing rate-dependent slowing of conduction preferentially in ischemic myocardium without altering refractoriness, providing a mechanistic explanation for the CAST trial findings.
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May explain CAST proarrhythmia in ischemia; leaves open human translation of rate-dependent effects.
Restivo et al. (1995) studied this question.
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