Why the study?
Does high blood pressure upregulate the Ca(L) channel alpha1C subunit in vascular smooth muscle cells?
Does high blood pressure upregulate the Ca(L) channel alpha1C subunit in vascular smooth muscle cells?
High blood pressure directly upregulates the Ca(L) channel alpha1C subunit in vascular smooth muscle cells in vivo, likely mediated by membrane depolarization, contributing to abnormal vascular tone in hypertension.
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May link pressure to Ca(L) upregulation in hypertension; hypothesis-generating and leaves open human translation.
Pesic et al. (2004) studied this question.
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