Key result
Vascular myocytes from hypertensive rats exhibit increased calcium channel activity and inward calcium currents compared to normotensive rats, suggesting altered calcium channel function or density.
Population
Vascular myocytes and isolated arterial segments from hypertensive animals and normotensive rats
Comparison
Depolarizing stimuli and calcium channel agonists vs Myocytes and arterial segments from normotensive…
Design
Preclinical
Authors
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Hypothesis-generating for calcium channel alterations in hypertension; leaves open human translation and therapeutic relevance.
Increased vascular reactivity in hypertension may be driven by an alteration in calcium channel function or an increase in calcium channel density in vascular myocytes.
Tostes et al. (1997) conducted a review in Hypertension. Hypertension vs. Normotension was evaluated on Calcium channel function and density in vascular myocytes. Vascular myocytes from hypertensive rats exhibit increased calcium channel activity and inward calcium currents compared to normotensive rats, suggesting altered calcium channel function or density.
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