July 1, 1998Experimental Biology and Medicine

Ion Channels in Vascular Smooth Muscle: Alterations in Essential Hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does angiotensin II type-1 receptor antisense gene therapy prevent pathophysiological alterations in hypertension models?

Population

Vascular smooth muscle cells in hypertension

Design

Review

Authors

JMJeffrey R. MartensTaste and Smell Clinic CGCraig H. GelbandUniversity of Iowa

Discussion

Member takes

Implication

Remains investigational for hypertension; hypothesis-generating for AT1 receptor antisense before any clinical translation.

Structured PICO

Does angiotensin II type-1 receptor antisense gene therapy prevent pathophysiological alterations in hypertension models?

Population

Vascular smooth muscle cells in hypertension (specifically referencing spontaneously hypertensive rats and prehypertensive rat pups)

Intervention

Angiotensin II type-1 receptor antisense gene therapy

Outcome

Prevention of pathophysiological alterations observed in hypertension including K+ channel alterationssurrogate

Gene therapy targeting the angiotensin II type-1 receptor may prevent pathophysiological ion channel alterations in hypertension.

Cite This Study

Martens et al. (1998) studied this question.

synapsesocial.com/papers/6a80c829d6e5d64541933db7 https://doi.org/10.3181/00379727-218-44286

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Ion Channels in Vascular Smooth Muscle: Alterations in Essential Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Ion Channels in Vascular Smooth Muscle: Alterations in Essential Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider