Key result
In the Schlager BPH mouse model of essential hypertension, complex remodeling of potassium, non-selective cation, and calcium channels in vascular smooth muscle cells contributes to membrane depolarization and increased vascular tone.
Why the study?
The mechanisms, molecular entities, and discrepant contributions of different vascular smooth muscle ion channels in hypertension remain unclear across models.
Population
Hypertensive mouse (BPH) and normotensive control (BPN) models
Comparison
Hypertensive mouse (BPH) vs normotensive control (BPN)
Design
Review
Authors
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Should not alter hypertension care; leaves open translation of vascular channel remodeling to human therapy.
This review details the complex electrical remodeling of vascular smooth muscle cells that contributes to increased vascular tone in the BPH mouse model of essential hypertension.
Daghbouche-Rubio et al. (2022) conducted a review in Essential hypertension. Vascular smooth muscle ion channel remodeling vs. Normotensive state (BPN mice) was evaluated. In the Schlager BPH mouse model of essential hypertension, complex remodeling of potassium, non-selective cation, and calcium channels in vascular smooth muscle cells contributes to membrane depolarization and increased vascular tone.
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