Why the study?
Does formaldehyde inactivation affect the ability of poliovirus to bind to hPVR, undergo structural conversion, and maintain RNA infectivity?
Population
Poliovirus (PV) and human poliovirus receptor (hPVR) in vitro models
Comparison
Formaldehyde inactivation vs Live poliovirus
Design
Preclinical
Authors
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Formaldehyde inactivation may impair poliovirus early steps in models; leaves open human vaccine implications from this animal study.
Does formaldehyde inactivation affect the ability of poliovirus to bind to hPVR, undergo structural conversion, and maintain RNA infectivity?
Formaldehyde inactivation of poliovirus impairs early viral replication steps, including receptor binding, structural conversion, and RNA infectivity.
Wilton et al. (2014) studied this question.
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