Key result
Irradiation of poliovirus particles at doses of 15-30 kGy significantly increased electrooxidation signals of capsid proteins, suggesting structural reorganization and insufficient D-antigen preservation.
Population
Poliovirus particles
Comparison
Inactivation by electrons accelerated with doses of 5 kGy, 10 kGy, 15 kGy, 25 kGy, 30 kGy vs formaldehyde inactivation
Design
Comparative electrochemical analysis
Authors
Loading...
Electrochemical D-antigen detection may enable rapid poliovirus assays; leaves open validation for vaccine applications.
Electrochemical profiling reveals that higher doses of ionizing radiation for poliovirus inactivation lead to increased structural reorganization of surface proteins and loss of D-antigen preservation.
Agafonova et al. (2024) studied Poliovirus inactivation. Ionizing radiation vs. Formaldehyde-inactivated poliovirus particles was evaluated on Electrooxidation signals of poliovirus capsid proteins. Irradiation of poliovirus particles at doses of 15-30 kGy significantly increased electrooxidation signals of capsid proteins, suggesting structural reorganization and insufficient D-antigen preservation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: