October 27, 2005Journal of VirologyOpen Access

Viral Protein VP4 Is a Target of Human Antibodies Enhancing Coxsackievirus B4- and B3-Induced Synthesis of Alpha Interferon

View Full Paper

Ask AI

Bookmark

Population

Peripheral blood mononuclear cells and plasma from 40 patients with insulin-dependent diabetes mellitus and…

Comparison

Incubation with CVB4E2 or CVB3 and plasma, with… vs H antigen or plasma without VP4 preincubation

Design

Preclinical

Authors

Discussion

Anti-VP4 antibodies may enhance CVB-induced IFN-alpha in patients; leaves open therapeutic targeting pending clinical validation.

Population

Peripheral blood mononuclear cells (PBMC) and plasma from 40 patients with insulin-dependent diabetes mellitus and 40 healthy subjects

Intervention

Incubation with CVB4E2 or CVB3 and plasma, with or without VP4 capsid proteins (VP4(CVB4) and VP4(CVB3)) or anti-VP4 antibodies

Comparator

H antigen or plasma without VP4 preincubation

Outcome

Alpha interferon (IFN-alpha) synthesis levelssurrogate

VP4 is the target of antibodies involved in the plasma-dependent enhancement of CVB4E2- and CVB3-induced IFN-alpha synthesis by PBMCs.

Chehadeh et al. (2005) studied this question.

View Full Paper

Ask AI

Bookmark