September 1, 2002Journal of General Virology

Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-α by peripheral blood mononuclear cells from patients with type 1 diabetes

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Structured PICO

Population

Patients with type 1 diabetes (n=56) and healthy subjects (n=20)

Intervention

In vitro stimulation of peripheral blood mononuclear cells (PBMCs) with coxsackievirus B4 (CVB4)

Comparator

PBMCs from healthy subjects

Outcome

IFN-alpha productionsurrogate

CVB4 can strongly induce IFN-alpha production by PBMCs from patients with type 1 diabetes through interactions with circulating and/or cell-bound IgGs.

Discussion

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Implication

Hypothesis-generating for CVB4 in type 1 diabetes pathogenesis; leaves open clinical relevance pending validation.

Cite This Study

Hober et al. (2002) studied this question.

synapsesocial.com/papers/6a83dd0fb0b8dfdc4c62dc89 https://doi.org/10.1099/0022-1317-83-9-2169

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Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-α by peripheral blood mononuclear cells from patients with type 1 diabetes

Structured PICO

Discussion

Implication

Cite This Study

Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-α by peripheral blood mononuclear cells from patients with type 1 diabetes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider