Population
Female, 12-19-week-old, and THOR mice
Design
Animal model study
Authors
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Supports atrial inflammation as POAF driver in female and young mice post-surgery; leaves open human translation and targeted interventions.
A mouse model demonstrates that cardiothoracic surgery increases POAF risk, particularly in females and 12-19-week-old mice, and is associated with upregulated atrial inflammatory cytokines.
Keefe et al. (2022) studied this question.
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