Why the study?
Does inoculation with ORF3-deficient mutant PCV2 alter viral pathogenesis compared to wild-type PCV2 in BALB/c mice?
Population
8-week-old BALB/c mice developed for PCV2 replication
Comparison
Inoculation with ORF3-deficient mutant PCV2 vs Inoculation with wild-type PCV2 and uninoculated…
Design
Preclinical
Follow-up
up to 42 days postinoculation
Authors
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ORF3 drives PCV2 pathogenesis in mice; hypothesis-generating for attenuated vaccines or interventions in swine.
Does inoculation with ORF3-deficient mutant PCV2 alter viral pathogenesis compared to wild-type PCV2 in BALB/c mice?
The ORF3 protein of PCV2 is dispensable for viral replication in vivo but plays a critical role in viral pathogenesis and the induction of pathological lesions.
Liu et al. (2006) studied this question.
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