Population
Porcine epithelial cells (in vitro model)
Design
Preclinical
Authors
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Highlights potential PCV2 inflammatory mechanism in swine; hypothesis-generating and requires validation before any translational consideration.
PCV2 ORF3 promotes proinflammatory cytokine secretion by facilitating the proteasomal degradation of RGS16, providing a molecular basis for the early inflammatory response in PCV2 infection.
Choi et al. (2015) studied this question.
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