Key result
Porcine RGS16 interacts with PCV2 ORF3 protein to facilitate nuclear translocation during viral infection.
Why the study?
The interaction between porcine circovirus type 2 ORF3 protein and regulator of G protein signalling 16 and its role in infection biology was not fully characterized.
Population
Porcine cells and porcine PBMC
Comparison
GST-linked ORF3 proteins from PCV2 genogroups and PCV1 in pull-down experiments; cell activation with mitogens, interferon inducers, norepinephrine
Design
In vitro interaction and expression analysis
Authors
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PCV2 ORF3 binds porcine RGS16 in vitro; leaves open functional role in pathogenesis and requires validation.
The interaction between porcine RGS16 and PCV2 ORF3 protein may play an important role in the infection biology of porcine circovirus by facilitating nuclear translocation.
Merlot et al. (2009) studied Porcine circovirus type 2 infection. PCV2 ORF3 protein was evaluated on Interaction between poRGS16 and ORF3 from PCV2. Porcine RGS16 interacts with the PCV2 ORF3 protein and appears to participate in its translocation into the cell nucleus, suggesting a role in PCV2 infection biology.
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