Key result
Heterozygous RGS16 polymorphisms linked to higher PCV2 viral loads versus homozygous genotypes in pigs.
Why the study?
RGS16 is known to be associated with PCV2, and PCV2 associated disease with high viral titer proliferation and decreased average daily gain is a serious problem in the swine industry.
Observational (n=142)
No
Absolute Event Rate: 3.59% vs 2.8%
p-value: p=0.03
Polymorphisms in the RGS16 gene are significantly associated with PCV2 viral load in Yorkshire pigs, suggesting a genetic basis for susceptibility to PCV2 associated disease.
Regulator of G protein signaling 16 (RGS16) is known to be associated with porcine circovirus type 2 (PCV2). PCV2 associated disease (PCVAD) is a serious problem in the swine industry. The representative symptoms of PCVAD are high viral titer proliferation and decreased average daily gain. In this study, we identified single nucleotide polymorphisms (SNPs) in the RGS16 region, including the upstream region. Of the 22 identified SNPs, rs332913874, rs326071195, and rs318298586 were genotyped in 142 Yorkshire pigs. These SNPs were significantly associated with the PCV2 viral load. Moreover, the haplotype combination was also related to the PCV2 viral load. The haplotype and diplotype analysis also had a significant difference with the PCV2 viral load. Taken together, our results suggest that RGS16 SNPs considerably affect the PCV2 viral load.
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Lee et al. (2021) conducted an observational in Porcine circovirus type 2 (PCV2) viral load (n=142). RGS16 single nucleotide polymorphisms (e.g., rs332913874 GA genotype) vs. Reference homozygous genotype (e.g., rs332913874 GG genotype) was evaluated on PCV2 viral load (Log PCV2 copies/mL) at 10 weeks of age for rs332913874 (p=0.03). Heterozygous genotypes of RGS16 polymorphisms (rs332913874, rs326071195, and rs318298586) were significantly associated with higher PCV2 viral loads compared to reference homozygous genotypes in naturally infected Yorkshire pigs.
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