Why the study?
Do terfenadine and astemizole inhibit HERG channels, explaining their QT-prolonging effects?
Population
Xenopus oocytes expressing human ether-a-go-go related gene encoded channels, as well as Kv1.1, IsK, and…
Design
Preclinical
Authors
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Supports HERG as mediator of QT prolongation by these agents; leaves open clinical translation to arrhythmia risk.
Do terfenadine and astemizole inhibit HERG channels, explaining their QT-prolonging effects?
The QT-prolonging effects of terfenadine and astemizole are likely mediated by their potent blockade of HERG potassium channels.
Suessbrich et al. (1996) studied this question.
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