Why the study?
Does the co-administration of terfenadine and ketoconazole cause torsades de pointes?
Population
1 patient taking the recommended prescribed dose of terfenadine in addition to cefaclor, ketoconazole, and…
Design
Case_report
Authors
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May warrant avoiding terfenadine with ketoconazole; leaves open population-level risk and causality.
Does the co-administration of terfenadine and ketoconazole cause torsades de pointes?
This case report provides the first evidence of torsades de pointes associated with recommended doses of terfenadine when co-administered with ketoconazole, likely due to metabolic inhibition.
Brian P. Monahan (1990) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: